Africa has historically been overlooked by the international oncology research community, resulting in the continent’s participation in less than 2% of all cancer clinical trials. Africa’s underrepresentation in cancer clinical trials has culminated in an alarming lack of data describing the effects of new cancer technologies and treatments in the world’s most genetically diverse population. Without these clinical data, African oncologists are unable to conclusively decide which treatment option is most suitable for their patients, instead relying on data and treatment practices tested in other ethnic groups. It is evident that cancer clinical trials involving African patients are essential, yet due to a lack of experience, Africa’s oncologists are under-equipped to contribute to and lead clinical research studies.
In 2021, BVGH and partners from Takeda Pharmaceutical Co., Ltd. and the Africa-Harvard-Oxford Consortium launched a digital clinical trial training program for cancer clinicians. Attracting more than 400 registrants from 37 countries, the course consisted of 14 weeks of live, interactive lectures introducing the basics of clinical research. Topics covered include the four phases of clinical trials, the drug development process, clinical practice and research ethics, and competitive grant writing – giving students a glimpse into the broader aspects of clinical trial processes. Participants’ response to the course was overwhelmingly positive, with 80% of attendees increasing their course exam scores. Nazima Dharsee from the Ocean Road Cancer Institute in Tanzania stated, “Every aspect of this course – from the management to the array of speakers and topics – was highly organized, informative, and rewarding. Clinical trials now seem possible and worthwhile.”
In the wake of the program’s success, BVGH launched the African Consortium for Cancer Clinical Trials Study Pool Mini-Grant program. Supported by Takeda, the Mini-Grant program enabled eight virtual training program participants to utilize and expand their clinical research skills through a funded research project of their choice. BVGH paired awardees with experienced cancer researchers from top international cancer institutions to act as mentors and thought partners during their research process. Data produced during the studies can be used by the Mini-Grant awardees to apply for larger, externally funded grants, thus creating the potential for extended clinical research opportunities involving Africa’s cancer patients.
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